This product is a unique probiotic formula designed to deliver active organisms that have been shown to promote healthy gut flora, protect intestinal integrity and boost immune function. Each capsule provides 7 proven probiotic strains chosen for their ability to withstand the harsh GI environment and adhere to the intestinal tract. Also included is Saccharomyces boulardii, an extensively researched microorganism shown to help restore microflora balance by enhancing “resident” probiotics. This product features BioShield Technology, an innovative process that preserves probiotic organisms and releases them on target, in the intestines, for maximum benefits.
Overview
The GI tract is a finely balanced environment where 300 different strains of bacteria compete for space and nutrients. When there is a healthy balance (eubiosis), few symptoms exist. However, dysbiosis can occur when an over-abundance of potentially harmful organisms prevail. The natural flora balance can be upset by medications (such as antibiotics, oral contraceptives, etc.), drinking chlorinated water, or eating too many processed foods.
Probiotics have been extensively studied and are characterized as having broad health benefits including (1) increasing populations of healthy bacteria following microflora imbalance; (2) supporting healthy bowel function; (3) increasing the production of important short chain fatty acids that provide energy to the GI lining; (4) creating a strong immune barrier and boosting immune function; (5) aiding in the digestion of difficult to break down compounds like lactose and casein; and (6) increasing detoxification of harmful compounds.
Because probiotics are live organisms, there are many challenges associated with manufacturing and distributing probiotic supplements. For a probiotic to be effective, it must be shelf stable through the expiration date and precisely delivered to the GI tract where it can have maximum benefit. Ortho Molecular uses BioShield Technology, an innovative manufacturing process, to ensure consistent, reliable results. The microorganisms in This product are first protected, sealed, and then freeze dried away from moisture, heat, light and oxygen. This puts the bacteria into a state of “hibernation,” allowing them to remain dormant until they are exposed to moisture in the GI tract. By utilizing advanced encapsulation technology, the probiotic organisms are preserved and then released on target for maximum benefit. This product also contains probiotic strains that have been strategically selected based on research supporting their survivability and adherence to the intestinal tract.
Lactobacillus acidophilus (La-14)†
Lactobacillus acidophilus is a beneficial bacterial strain that is normally found in the human intestinal tract and mouth and is commercially used in dairy products for the production of acidophilus-type yogurt.
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
L. acidophilus ferments various carbohydrates producing lactic acid, a short chain fatty acid that increases the absorption and bioavailability of minerals. This includes calcium, copper, magnesium, and manganese. [1] The production of lactic acid also promotes health by creating an inhospitable environment for invading microbes.[1] L. acidophilus has been shown to protect intestinal cells by competing for adhesion space in the G.I. against harmful bacteria, such as E. coli. [2] The L. acidophilus La-14 strain has been specifically chosen for use in this product because of its strong adherence and survival attributes. It has been demonstrated to tolerate exposure to stomach acid, bile salts and the ability to withstand antibiotics including Ciproflaxin, Polymyxin B, and Tetracycline. [2]
Lactobacillus paracasei (Lpc-37)†
Lactobacillus paracasei is a lactic acid secreting strain that has been shown to protect against the harmful effects of bacteria such as Staphylococcus aureus.[3] Lactobacillus paracasei colonizes the intestinal tract first then reinforces defense mechanisms by supporting immune system response. It does this by supporting T-helper cell (white blood cell) production, and secreting sIgA- an antibody that is critical for supporting intestinal immunity. [4] L. paracasei Lpc-37 is a stomach acid- resistant strain and has also has been shown to withstand antibiotics such as Ciproflaxin and Vancomycin. [5]
Bifidobacterium bifidum (Bb-02)†
perfringens, due to the production of bacteriocins (lethal proteins) that inhibit bacterial growth. [10] Studies have also demonstrated that L. plantarum helps boost the immune response by stimulating Th1-mediated immunity. [11]
Lactobacillus rhamnosus (Lr-32)†
Lactobacillus rhamnosus has been found to be beneficial in the expelling of parasites. In a study examining exposure to the parasite Trichuris muris, L. rhamnosus significantly enhanced worm expulsion. It has also been shown to promote GI health by increasing intestinal cell replication. [12]
Saccharomyces boulardii†
Saccharomyces boulardii is a probiotic yeast that was first isolated from the skin of the tropical fruits lychee and mangosteen in 1923 by French scientist Henri Boulard following the observation that mangosteen consumption controlled occasional diarrhea in natives of Southeast Asia. S. boulardii plays a role in supporting immune defense by increasing levels of the crucial antibody, secretory IgA, creating a first line of defense that helps bind and clear harmful bacteria. [13]
Directions
1 capsule per day or as recommended by your health care professional.
Does Not Contain
Wheat, gluten, soy, corn, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or preservatives.
Cautions
If you are pregnant or nursing, consult your physician before taking this product.
Bifidobacterium bifidum is predominantly found in the colon. Bifidobacterium is a normal resident of healthy infant GI tracts and usually colonizes within 4 days of life. [6] B. bifidum has been shown to effectively compete with harmful bacteria such E. coli, Staphyolococcus aureus and Camplylobacter jejuni suggesting that B. bifidum’s lactic acid and acetic acid production provides an antagonistic action against pathogens to help maintain microflora balance.[7]
Bifidobacterium lactis (BI-04)†
Bifidobacteria lactis is predominantly found in the colon. A double-blind, randomized placebo-controlled trial on subjects receiving B. lactis or placebo for 8 weeks found that B. lactis supported a balanced immune response in individuals hypersensitivetoenvironmentalallergens.[8] Studiesexamining immune development and dietary supplementation with B. lactis have shown that B. lactis supports G.I. health by reducing intestinal permeability. [9]
Lactobacillus plantarum (Lp-115)†
Lactobacillus plantarum is a beneficial bacteria commonly found in fermented foods including sauerkraut, pickles, brined olives and sourdough. L. plantarum has been found to compete against strains of Clostridium difficile and Clostridium
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
References
- Lipski E. (1996) Digestive Wellness. New Canaan, CT: Keats Publishing.
- Danisco. Lactobacillus acidophilus La-14 probiotic identity card.
- Bendali F, Madi N, Sadoun D. Beneficial effects of a strain of Lactobacillus paracei subsp. paracasei in Staphylcoccus aureus-induced intestinal and colonic injury. Int J Infect Dis 2011;15(11):e787-94.
- Chiang SS, Pan TM. Beneficial effects of Lactobacillus paracasei subsp. paracei NTU 101 and its fermented products. Appl Microbiol Biotechno 2012 Feb;93(3):903-16.
- Danisco. Lactobacillus paracasei Lpc-37 probiotic identity card.
- Bezirtzoglou E, Stavropoulou. Immunology and probiotic impact of the newborn and young children intestinal microflora. Anaerobe 2011; Dec;17(6):369-74.
- Fooks LJ, Gibson GR. Mixed culture fermentation studies on the effects of synbiotics on the human intestinal pathogens Campylobacter jejuni and Escherichia coli. Anaerobe 2003;9(5):231-42.
- Singh A, Hacini-Rachinel F, Gosoniu M, et al. Immune- modulatory effect of probiotic Bifidobacterium
lactis NCC2818 in individuals suffering from seasonal allergic rhinitis to grass pollen: an exploratory, randomized, placebo-controlled clinical trial.Eur J Clin Nut 2013 Feb;67(2):161-7. - Lewis MC, Patel DV, Fowler J, Duncker S, Zuercher AW, Mercenier A, Bailey M. Dietary supplementation with Bifidobacterium lactis NCC2818 from weaning reduces local immunoglobulin production in lymphoid-associated tissues but increases systemic antibodies in healthy neonates. Br J Nutr 2013;11:1-10.
- Schoster A, Kokotovic B, Permin A, Pedersen PD,
Bello FD, Guarabassi L. In vitro inhibition of Clostridium difficile and Clostridium perfringens by commercial probiotic strains. Anarobe 2013; 20:36-41. - Chytilová M, Mudroňová D, Nemcová R, Gancarčíková S, Buleca V, Koščová J, Tkáčiková L. Anti-inflammatory
and immunoregulatory effects of flax-seed oil and Lactobacillus plantarum – BiocenolTM LP96 in gnotobiotic pigs challenged with enterotoxigenic Escherichia coli. Res Vet Sci 2013 Feb 25. pii: S0034-5288(13)00056-8. - 12. McClemens J, Kim JJ, Wang H, Mao YK, Collins M, Kunze W, Bienenstock J, Forsythe P, Khan WI. Lactobacillus Rhamnosus (JB-1) Ingestion Promotes Innate Host Defense in an Enteric Parasitic Infection. Clin Vaccine Immunol 2013; Mar 27.
- 13. Rodrigues ACP, Cara DC, Fretez SHGG, et al. Saccharomyces boulardii stimulates sIgA production and the phagocytic system of gnotobiotic mice. J of Applied Micro 2000; 89(3):404-414.